Table of Contents
Overview
New York, NY – August 14, 2025 : The Global Mice Model Market is projected to reach USD 3.27 Billion by 2034, up from USD 1.68 Billion in 2024. This represents a CAGR of 6.9% from 2025 to 2034. In 2024, North America dominated with a 39.4% share, generating USD 661.9 million in revenue. Growth is fueled by demand in oncology, immunology, and rare-disease research. Genetically engineered strains are in high demand for their strong translational relevance. CRISPR/Cas9 remains the fastest-growing technology, offering shorter model generation times and reduced costs for researchers worldwide.
North America maintains its lead in the market due to strong R&D investment and pharmaceutical activity. However, Asia-Pacific is rapidly expanding. China, Japan, and South Korea are investing in local breeding facilities and advanced research infrastructure. Contract research organizations (CROs) are increasing their market share through outsourced studies. The use of humanized immune system mice and patient-derived xenograft (PDX) models is expanding. These models are essential in validating immuno-oncology therapies, driving further adoption among pharmaceutical companies and research institutions.
Regulatory pressures are encouraging the development of alternative and refined research methods. While such regulations can challenge traditional practices, they also drive innovation in model development. Advanced models now offer higher fidelity to human biology and improved ethical standards. The Jackson Laboratory is a leading provider of thousands of disease models. These are available as spontaneously developed or genetically engineered strains. They serve a wide range of research purposes, from oncology to immunology, supporting global efforts in drug discovery and development.
In June 2025, the Jackson Laboratory announced humanized mice models that closely replicate human physiology and disease pathways. These advanced models enhance research reliability, accuracy, and predictability. They are proving especially valuable in immuno-oncology, infectious diseases, and autoimmune research. By mimicking human immune responses, these models enable better preclinical testing. As demand for personalized medicine grows, humanized mice offer researchers a vital platform for studying drug responses in a controlled and reproducible environment. This innovation is set to influence future market growth.
Mice models offer many practical benefits for research. They are small, have a short generation time, and an accelerated lifespan, where one mouse year equals roughly 30 human years. This makes them cost-efficient and space-saving in laboratories. Genetic engineering allows the creation of customized strains. These may host patient-derived tumors, carry specific gene mutations, or possess human immune systems. Such adaptability enables precise disease modeling and targeted therapy research. As technology advances, mice models remain an indispensable tool in biomedical and pharmaceutical studies.
Key Takeaways
- In 2024, the global Mice Model market earned US$ 1.68 billion, growing at a CAGR of 6.9% toward US$ 3.27 billion by 2034.
- Among model types, Genetically Modified Mice dominated in 2023 with a 38.5% market share, outperforming Outbred, Inbred, and Hybrid Mice categories.
- Breeding Services led the service segment in 2024, capturing 47.2% of the market, ahead of cryopreservation, rederivation, quarantine, and other service offerings.
- CRISPR/Cas9 technology topped the technology segment with 46.9% revenue share, surpassing embryonic stem cell injection, nuclear transfer, microinjection, and other methods.
- Oncology applications took the lead in 2024 with 32.5% market share, followed by neurology, cardiovascular diseases, immunology, and other medical research areas.
- Pharmaceutical and biotechnology companies held the largest end-user share in 2024 at 41.6%, ahead of research laboratories, CROs, and hospitals or clinics.
- North America emerged as the leading region in 2023, securing 39.4% of the global Mice Model market share.
Regional Analysis
North America dominates the global mice model market with a 39.4% share. The region’s growth is supported by strong advancements in genetic engineering and a well-established research ecosystem. Increasing demand for personalized medicine is a key driver. North America’s leadership in biomedical R&D strengthens its market position. The presence of top research institutions and funding opportunities adds to this advantage. These factors ensure steady market growth in the coming years. The region continues to be a hub for innovative mice model development.
In February 2025, Professor Jiyue Zhu from WSU College of Pharmacy and Pharmaceutical Sciences developed mice with human-like short telomeres. This breakthrough allows for aging studies that closely mimic human biology. Normally, mice have telomeres up to 10 times longer than humans. The new model enables research on cellular aging and cancer. Professor Zhu received US$5 million in grants to expand this work. This innovation highlights North America’s leading role in advanced biomedical research and specialized mouse model creation.
Segmentation Analysis
The Genetically Modified Mice segment dominated the mice model market in 2024, holding over 38.5% share. These models are vital for biomedical research and drug discovery. They mimic human diseases at a genetic level, enabling studies on cancer, diabetes, and neurological disorders. CRISPR-Cas9 has further boosted demand by enabling precise and cost-effective gene editing. Key companies such as Charles River Laboratories and The Jackson Laboratory lead in this area. For example, in November 2024, Taconic Biosciences expanded production with a new facility in Seattle to meet growing research needs.
Breeding services held the largest share in 2024, at 47.2%. These services are essential for producing high-quality, genetically uniform mice models. They support consistent supply for drug discovery, genetic research, and disease modeling. Demand for genetically modified mice drives the need for expert breeding programs. Large-scale production of specific strains ensures continuity in long-term studies. In February 2025, researchers at the Canberra breeding facility worked on saving smoky mice, a native species, from extinction, highlighting breeding’s vital role in conservation and research.
CRISPR/Cas9 technology accounted for 46.9% of the global market in 2024. It enables precise and targeted DNA edits, making genetic modification of mice more efficient. Researchers use it to study genes linked to cancer, neurological, and metabolic disorders. Its cost-effectiveness and speed have revolutionized model creation for both academic and pharmaceutical research. The technology supports the rising need for personalized medicine and tailored disease models. By allowing scalable and accurate modifications, CRISPR/Cas9 has become a preferred tool in developing custom mice that mimic human genetic conditions.
Oncology led the mice model market by application with 32.5% share in 2024. Cancer research relies heavily on mice models to study tumor progression, metastasis, and therapy effectiveness. Genetically modified mice are widely used to replicate specific cancer types. This helps in testing drugs, studying tumor biology, and developing immuno-oncology treatments. The growing global cancer burden and demand for precision medicine have boosted this segment. Companies like Charles River Laboratories and Taconic Biosciences supply models specialized for oncology research, ensuring continued dominance in this field.
Pharmaceutical and biotechnology companies dominated the market by end-user, holding 41.6% share in 2024. These companies depend on mice models for drug discovery, preclinical testing, and disease modeling. They require specialized models for complex diseases, including genetic disorders and neurological conditions. The rise in biologics, gene therapies, and targeted treatments drives demand for high-quality models. Accurate replication of human disease conditions is critical for safety and efficacy testing. As drug pipelines expand, these companies remain the largest consumers of mice models, reinforcing their leading role in the market.
Key Players Analysis
Charles River Laboratories International, Inc. is a leading provider of preclinical and clinical contract research services in the mice model market. The company offers genetically modified, inbred, and outbred mice for drug discovery, disease research, and safety testing. Its services include breeding, quarantine, and testing to support pharmaceutical and biotech companies worldwide. Charles River focuses on delivering reliable and ethically sourced models. Its offerings help accelerate research and development processes. The company plays a key role in enabling scientific breakthroughs across multiple therapeutic areas.
The Jackson Laboratory is a renowned nonprofit research institution specializing in genetics and biomedical research. It produces high-quality, genetically defined mouse models, including inbred, hybrid, and genetically modified strains. These models are essential for cancer, neurology, immunology, and genetic disease research. The organization supports academic, government, and pharmaceutical sectors with precision-engineered mouse models. Its work enhances drug discovery and disease modeling capabilities. The Jackson Laboratory’s expertise ensures researchers have access to consistent and reproducible models for critical biomedical studies.
Emerging Trends
- Rise of Genetically Engineered Mice: More research labs are using genetically engineered mice. These are specially bred to have specific changes in their genes. Such mice can mimic human diseases like cancer, diabetes, or neurological disorders. This makes it easier for scientists to study how these illnesses develop over time. It also helps them test possible treatments before moving to human trials. By using these models, researchers gain more accurate insights into disease mechanisms. This trend is growing as demand for better preclinical testing increases. It also supports faster drug development and reduces the chances of late-stage clinical trial failures.
- Shift Toward Humanized Mice: Humanized mice are becoming more popular in research labs. These mice are developed to have human cells, tissues, or immune systems. This allows scientists to study human-specific diseases with greater accuracy. They are especially valuable in cancer immunotherapy and infectious disease research. For example, they can be used to test how the human immune system responds to new treatments. Humanized mice also help in understanding how viruses or bacteria affect human biology. This makes them a key tool in developing vaccines and targeted therapies. Their growing use is changing the way scientists approach medical research.
- Growth in Personalized Medicine Research: Mice models are now playing a bigger role in personalized medicine. Scientists can create mice with specific genetic traits that match certain patient groups. This helps in testing how different people might respond to the same drug. By studying these models, researchers can develop targeted treatments for individuals. It also allows them to identify potential side effects before testing in humans. Personalized medicine aims to make treatments more effective and safer. The use of mice models in this field is speeding up the process of developing custom therapies. This trend will likely keep growing in the future.
- Integration of CRISPR Gene-Editing Technology: CRISPR technology is making genetic editing in mice faster and more accurate. With this tool, scientists can create precise changes to a mouse’s DNA. This helps in developing models for rare diseases or unique genetic conditions. It also reduces the time needed to build complex disease models. Researchers can now study the effects of specific genetic mutations more effectively. CRISPR also makes it possible to mimic human genetic disorders more closely. This speeds up drug discovery and testing. The integration of CRISPR into mice model development is transforming biomedical research and enabling more targeted medical solutions.
- Increase in Preclinical Drug Testing: Mice models are essential in the early stages of drug testing. They help researchers understand if a new drug is safe and effective before human trials. This reduces risks and costs for pharmaceutical companies. As more drugs are developed, the demand for mice in preclinical studies is rising. These models allow scientists to identify potential problems early. They also provide valuable data on how a drug works in living organisms. This step is critical for meeting regulatory approval standards. With the growth of biotechnology and pharmaceuticals, mice models will remain a vital part of drug research.
Use Cases
- Cancer Research: Mice are often used to grow tumors that act like human cancers. These models let scientists test new cancer drugs in realistic conditions. By studying how tumors grow and react to treatments, researchers can find out which drugs are most effective. Mice also help in exploring how cancer spreads and how the immune system responds. This process improves the chances of developing successful therapies. Many breakthrough cancer medicines were first tested on mice. Using these models speeds up research and ensures only the most promising drugs move forward to human trials. This makes cancer studies safer and more precise.
- Neurological Disorder Studies: Specially bred mice can develop diseases like Alzheimer’s or Parkinson’s. These models help researchers see how such conditions start and progress over time. Scientists can track brain changes and test new therapies in controlled settings. This approach is vital for finding ways to slow or stop these disorders. Mice are also used to study memory loss, nerve damage, and other symptoms linked to brain diseases. The data gained can guide better treatments for patients. Without these models, studying complex neurological conditions in humans would be much harder and riskier. Mice research helps pave the way for medical breakthroughs.
- Infectious Disease Research: Mice can be infected with viruses or bacteria to understand how diseases spread. Researchers use them to study how the immune system reacts to infections. These models are especially useful for vaccine development. They allow scientists to test if a vaccine works before trying it in humans. Mice models have played a key role in research on flu, COVID-19, and other dangerous diseases. They help in identifying effective treatments and prevention methods. By observing how the body fights infections in mice, scientists can design safer, faster, and more reliable health solutions for humans.
- Diabetes and Metabolic Disorder Testing: Some mice are genetically modified to develop diabetes or other metabolic problems. These models help scientists test new treatments for controlling blood sugar. They also allow researchers to see how diabetes affects organs over time. Mice can be studied in different stages of the disease, from early symptoms to severe complications. This gives valuable insights into how to prevent damage and improve patient care. Testing on mice reduces risks before trying treatments in humans. It also speeds up the process of finding effective medicines and lifestyle approaches for managing metabolic disorders.
- Toxicology and Safety Testing: Before a new drug or chemical is given to humans, it must be tested for safety. Mice are often used to check for harmful effects and find safe dosage levels. Researchers can monitor how the body processes a substance and if it causes side effects. This process ensures that only safe products move forward to human testing. Toxicology studies in mice also help identify long-term risks. They are vital for protecting public health and ensuring regulatory compliance. Without these tests, the chance of dangerous reactions in human trials would be much higher.
Conclusion
The mice model market is set for steady growth, driven by advances in genetic engineering, rising demand for personalized medicine, and expanding applications in drug discovery. Humanized and genetically modified mice are becoming essential tools for studying complex diseases like cancer, neurological disorders, and infectious illnesses. CRISPR technology is making model development faster and more cost-effective, boosting adoption among pharmaceutical companies, research labs, and CROs.
While regulations encourage ethical practices, they also push innovation in model accuracy and efficiency. With strong investments in research and growing global collaboration, mice models will remain a vital part of preclinical testing and biomedical research in the years ahead.
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