HLA Typing Market Expected To Surpass US$ 2.2 Billion By 2032

Trishita Deb
Trishita Deb

Updated · Feb 5, 2025

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Introduction

New York, NY – February 05, 2025 – The HLA Typing Market size is expected to be worth around USD 2.2 Billion by 2032 from USD 1.3 Billion in 2023, growing at a CAGR of 6.4% during the forecast period from 2023 to 2032.

Human Leukocyte Antigen (HLA) typing is a critical process in organ, tissue, and bone marrow transplantation. It determines compatibility between a donor and recipient by identifying specific HLA markers on white blood cells. These markers help the immune system distinguish between the body’s own cells and foreign invaders. A precise HLA match is essential to reduce the risk of transplant rejection and graft-versus-host disease (GVHD), which can lead to severe complications.

HLA typing is widely used in kidney, liver, heart, and stem cell transplants, ensuring higher success rates and better patient outcomes. Advances in molecular techniques, such as next-generation sequencing (NGS) and polymerase chain reaction (PCR), have improved HLA matching accuracy. These innovations contribute to personalized medicine, enhancing donor selection and immune response prediction.

Global healthcare organizations, including the World Health Organization (WHO) and the National Marrow Donor Program (NMDP), emphasize the importance of HLA testing in donor registries. Increased awareness and technological advancements are driving demand for HLA typing in precision medicine, autoimmune disease research, and transfusion therapy. With continued progress, HLA typing remains a cornerstone of immunogenetics, improving transplant success and patient survival rates worldwide.

HLA Typing Market Size

Key Takeaways

  • In 2022, the reagents & consumables segment led the market, holding a 55.3% revenue share among products.
  • The molecular assay segment dominated in technology, accounting for 52% of the total market revenue.
  • Diagnostics emerged as the leading application, generating the highest market revenue in 2022.
  • Hospitals & transplant centers held the largest market share among end users and are projected to experience the fastest CAGR from 2023 to 2032.
  • North America remained the dominant regional market, contributing 47.9% of the total revenue.
  • Europe also played a significant role, securing a 28.6% market share.
  • The Asia Pacific market is anticipated to expand at a CAGR of 8.6% over the forecast period.

Segmentation Analysis

  • By Product Analysis:  The HLA typing market is divided into instruments, services, software, and reagents & consumables. In 2022, the reagents & consumables segment held the largest revenue share at 55.3%, driven by its essential role in diagnostic test kits for precise and rapid analysis. Key industry players, such as Thermo Fisher Scientific Inc., reported high demand from the healthcare, pharmaceutical, and clinical sectors.
  • By Technology Analysis: The HLA typing market is segmented into molecular assay, sequence-based molecular assay, and non-molecular assay. In 2022, the molecular assay segment accounted for 52% of market revenue, owing to its efficiency in parallel sequencing and probe-based hybridization for HLA typing. Molecular techniques, including PCR-based sequencing, offer real-time data interpretation, faster processing, and multi-sample testing, making them the most preferred method for transplant compatibility testing.
  • By Application Analysis: The HLA typing market is categorized into diagnostics and research applications. In 2022, the diagnostics segment led with the highest revenue share and a 6.7% CAGR due to increased outsourcing of laboratory services by hospitals and transplant centers. HLA typing diagnostics help detect conditions such as rheumatoid arthritis, Behçet’s disease, and narcolepsy, contributing to its strong market demand. The research segment is expected to grow significantly in the coming years.
  • By End-User Analysis: The end-user segment includes hospitals & transplant centers, academic institutes, commercial service providers, and others. In 2022, hospitals and transplant centers held the highest revenue share at 56%, driven by the availability of advanced medical devices and skilled professionals. North America has around 147 liver transplant centers, emphasizing the segment’s dominance. Academic institutes are also expected to witness significant growth due to expanding HLA typing services.

Market Dynamics

  • Driver: The increasing need for organ transplants significantly drives the Human Leukocyte Antigen (HLA) typing market. Accurate HLA matching is crucial to prevent transplant rejection and ensure successful outcomes. As the global population ages and the prevalence of chronic diseases rises, the demand for organ transplants has escalated. This surge necessitates precise HLA typing to match donors and recipients effectively, thereby propelling market growth. According to the World Health Organization (WHO), enhancing transplant compatibility through accurate HLA typing is vital for improving patient survival rates.
  • Trend: A notable trend in the HLA typing market is the adoption of Next-Generation Sequencing (NGS) technologies. NGS offers high-resolution typing, enabling detailed analysis of HLA genes and improving matching accuracy between donors and recipients. This technology allows for the identification of rare and novel alleles, enhancing the precision of transplantation procedures. The implementation of NGS in HLA typing is becoming more widespread, reflecting a shift towards more advanced and reliable genetic analysis methods in clinical settings.
  • Restraint: Despite technological advancements, the high costs associated with advanced HLA typing methods, such as NGS, pose a significant restraint. These sophisticated techniques require substantial investment in equipment, reagents, and skilled personnel, making them less accessible, especially in low-resource settings. The financial burden can limit the widespread adoption of precise HLA typing, potentially affecting the availability of compatible organs for transplantation and hindering market growth.
  • Opportunity: The expansion of stem cell and bone marrow transplantation presents a significant opportunity for the HLA typing market. Accurate HLA matching is critical in these procedures to prevent graft-versus-host disease and ensure transplant success. As research progresses and the indications for stem cell therapies broaden, the demand for precise HLA typing is expected to increase. This trend offers potential for market expansion, particularly with the development of cost-effective and efficient typing methodologies to support the growing need for compatible stem cell transplants.

Emerging Trends in HLA Typing

  • Advanced Sequencing Technologies: The adoption of third-generation sequencing methods, such as PacBio and nanopore sequencing, is improving HLA typing by providing more precise results and reducing ambiguities.
  • Integration with Next-Generation Sequencing (NGS): NGS platforms are increasingly used for HLA typing, allowing for high-resolution analysis and the ability to detect rare alleles, thereby improving donor-recipient matching.
  • Development of Specialized Software Tools: New computational tools are being created to analyze sequencing data more efficiently, enhancing the speed and accuracy of HLA typing.

Use Cases of HLA Typing

  • Organ and Stem Cell Transplantation: Accurate HLA matching between donors and recipients is essential to prevent transplant rejection. For instance, in kidney transplants, mismatched HLA can lead to graft failure. Studies have shown that well-matched HLA pairs significantly increase the success rate of transplants.
  • Disease Association Studies: Certain HLA types are linked to autoimmune diseases. For example, HLA-B27 is associated with a higher risk of developing ankylosing spondylitis. Identifying these associations helps in understanding disease mechanisms and developing targeted therapies.
  • Adverse Drug Reaction Prediction: HLA typing can predict susceptibility to drug hypersensitivity reactions. For example, individuals with the HLA-B 57:01 allele are at increased risk of hypersensitivity to the HIV drug abacavir. Screening for this allele before prescribing can prevent adverse reactions.

Conclusion

In conclusion, Human Leukocyte Antigen (HLA) typing plays a pivotal role in organ, tissue, and stem cell transplantation by ensuring compatibility between donors and recipients, thereby reducing the risk of rejection and complications like graft-versus-host disease. Advancements in molecular technologies, particularly Next-Generation Sequencing (NGS), are enhancing the precision of HLA matching, driving demand in both clinical and research applications.

Despite challenges such as high costs and limited accessibility in low-resource regions, the market is poised for growth, fueled by rising transplant needs, the expanding role of stem cell therapy, and technological innovations. With continued progress in sequencing techniques and computational tools, HLA typing will remain central to improving transplant success rates and patient outcomes worldwide.

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Trishita Deb

Trishita Deb

Trishita has more than 8+ years of experience in market research and consulting industry. She has worked in various domains including healthcare, consumer goods, and materials. Her expertise lies majorly in healthcare and has worked on more than 400 healthcare reports throughout her career.

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