Table of Contents
Overview
New York, NY – Jan 02, 2026 – The Global Endoscopic Clips Market size is expected to be worth around USD 849.9 Million by 2033 from USD 420.1 Million in 2023, growing at a CAGR of 7.3% during the forecast period from 2024 to 2033.
The global endoscopic clips market continues to demonstrate steady expansion, supported by rising adoption of minimally invasive procedures and increasing prevalence of gastrointestinal disorders. Endoscopic clips are widely used in clinical practice for tissue approximation, hemostasis, perforation closure, and post-procedural bleeding control. Their role has become increasingly important as healthcare systems emphasize patient safety, reduced recovery time, and procedural efficiency.
Growth of the market can be attributed to technological advancements in endoscopic devices, including improved clip designs, enhanced rotational control, and stronger closure force. These innovations are enabling physicians to perform complex therapeutic endoscopic interventions with higher precision and reliability. In addition, increasing awareness among clinicians regarding the clinical benefits of endoscopic clipping is supporting broader utilization across hospitals and ambulatory surgical centers.
Rising geriatric population and growing incidence of colorectal cancer, peptic ulcers, and inflammatory bowel disease are further contributing to demand. Favorable reimbursement frameworks in developed healthcare systems, combined with expanding endoscopy infrastructure in emerging economies, are also strengthening market penetration.
Manufacturers are focusing on product differentiation, regulatory approvals, and strategic collaborations to expand their geographic presence. Emphasis is being placed on single-use devices to reduce infection risk and comply with stringent sterilization standards.
Looking ahead, the endoscopic clips market is expected to witness sustained growth, supported by continuous innovation and increasing procedural volumes. The market outlook remains cautiously optimistic, driven by clinical effectiveness, improving patient outcomes, and the ongoing shift toward minimally invasive gastrointestinal therapies.
Key Takeaways
- Market Size: The global endoscopic clips market is projected to reach approximately USD 849.9 billion by 2033, rising from USD 420.1 billion recorded in 2023.
- Market Growth: Market expansion is anticipated at a compound annual growth rate (CAGR) of 7.3% over the forecast period spanning 2024 to 2033.
- Application Analysis: In 2023, the hemostasis application segment accounted for the largest share of the global market, contributing 58.1% of total revenue.
- End-Use Analysis: Hospitals represented the leading end-user segment, generating 51.6% of the overall market revenue during the same year.
- Regional Analysis: North America continued to dominate the global endoscopic clips market, holding more than 37.8% of total revenue share.
- Technological Advancements: Ongoing innovations in endoscopic clip design and functional performance are improving procedural accuracy and clinical outcomes.
- Increasing Applications: Utilization of endoscopic clips is expanding across hemostasis, tissue closure, and lesion marking in endoscopic interventions.
- Rising Healthcare Expenditure: Increased investment in healthcare infrastructure and medical services is supporting sustained market growth.
- Patient Preference: Growing preference for minimally invasive treatment options among patients is accelerating the adoption of endoscopic clip technologies.
Regional Analysis
North America held a leading position in the global endoscopic clips market in 2023, capturing approximately 37.8% of total revenue. Market leadership in the region is supported by the high incidence of gastrointestinal disorders, a well-developed healthcare infrastructure, and substantial investments in advanced medical technologies. The availability of a highly skilled clinical workforce further strengthens procedural adoption across hospitals and specialty care centers.
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The presence of major industry participants, including Cook Medical and Boston Scientific Corporation, plays a critical role in driving innovation and accelerating the commercialization of advanced endoscopic solutions. These companies continue to focus on product development and clinical efficiency, reinforcing the region’s competitive advantage.
In addition, the strong regional focus on minimally invasive surgical techniques has significantly increased the utilization of endoscopic clips, as these procedures offer reduced recovery times and improved patient outcomes. Demographic trends also contribute to sustained demand, particularly the growing elderly population that requires frequent gastrointestinal diagnostic and therapeutic interventions.
According to data published by the U.S. Census Bureau, the population aged 65 years and above is expected to reach 94.7 million by 2060, indicating a substantial rise in the patient pool for endoscopic procedures. Furthermore, favorable reimbursement frameworks and widespread access to advanced healthcare facilities continue to enhance the adoption and accessibility of endoscopic clip technologies across North America.
Use Cases for Endoscopic Clips
- Stop active gastrointestinal bleeding (mechanical hemostasis)
- Endoscopic clips are commonly used to clamp a bleeding vessel in peptic ulcers and other non-variceal lesions.
- In a randomized trial for peptic ulcer bleeding, initial hemostasis was 98.4% with over-the-scope clips (OTSC) vs 78.4% with through-the-scope clips (TTS), and 30-day rebleeding was 1.6% vs 3.9%.
- Rescue therapy when standard bleeding control fails
- A clinically important share of non-variceal bleeding can remain uncontrolled with conventional approaches; this is the main “rescue” space for stronger mechanical devices.
- Conventional endoscopic treatments have been reported as unable to control bleeding in up to ~20% of non-variceal GI bleeding cases in published reviews.
- Prevent delayed bleeding after colon polypectomy/EMR (prophylactic clipping)
- Delayed post-polypectomy bleeding is uncommon overall but rises sharply with larger lesions.
- Published data describe overall delayed bleeding of ~0.3%–1.2%, increasing to about 6.2% for lesions >20 mm; therefore, prophylactic clipping is used mainly for higher-risk resections.
- Close iatrogenic perforations and procedure-related wall injuries
- Clips are used to close small-to-moderate perforations caused during EMR/ESD, dilation, or other therapeutic procedures.
- A large review reported successful closure in approximately 90% of through-the-scope clip applications and 87.8% for over-the-scope clip applications (across closure indications).
- Seal leaks and fistulas (defect closure across anastomoses or chronic tracts)
- Clips are used to close post-surgical leaks and selected fistulas, often when the defect is small and tissue edges can be approximated.
- A recent synthesis reported technical success ~86.7% and clinical success ~72.6% for clip-based leak closure; outcomes are typically lower than for fresh perforations because chronic tracts heal less reliably.
Emerging Trends in Endoscopic Clips
- OTSC moving earlier in the bleeding algorithm for high-risk lesions
- Evidence is supporting OTSC as a first-line option in selected high-risk ulcer bleeding, driven by lower rebleeding and higher immediate control.
- A 2025 meta-analysis reported OTSC associated with lower 30-day rebleeding (RR ~0.54) and a reported number needed to treat (NNT) of ~9 to prevent one rebleed.
- Rapid adoption of newer “enhanced” through-the-scope closure designs
- Newer TTS designs (example: twin-clip concepts) are expanding the size of defects that can be closed without switching to larger devices.
- In a 2025 clinical report, a TTS twin-clip approach achieved 98.7% complete closure (78/79 defects) with a median closure time of 15 minutes.
- More selective prophylactic clipping based on measurable risk (size, location, blood thinners)
- Practice is moving from “clip everyone” to “clip the patients and lesions most likely to bleed,” because baseline delayed bleeding is low for small lesions.
- For large proximal lesions (≥20 mm), prophylactic clipping has been reported with reduced delayed bleeding (example subgroup result: 4.0% vs 7.7%, RR ~0.51) and published NNT signals such as ~32 for proximal ≥20 mm lesions (stronger benefit signals in antithrombotic subgroups).
- More combination closure strategies for leaks/fistulas (clips + other modalities)
- Because clinical success for chronic leaks/fistulas is lower than technical success, combined approaches are increasingly used (clips plus adjunctive tissue preparation/closure methods) to improve healing.
- This shift is consistent with published gaps between technical success (~86.7%) and clinical success (~72.6%) for leak closure, showing that “closing the hole” does not always equal “durable healing.”
- Clip-based fixation to address stent migration (clips used as anchors)
- Stent migration remains a material problem, and clip-anchoring (including OTSC anchorage) is being used more often, especially for fully covered stents.
- A 2025 systematic review of stent migration factors reported a mean migration rate ~17.2% across studies and stent types, supporting demand for fixation methods; systematic review work has concluded OTSC anchorage lowers migration risk versus no fixation.
Frequently Asked Questions on Endoscopic Clips
- What materials are commonly used in endoscopic clips?
Endoscopic clips are typically manufactured using biocompatible metals such as stainless steel, titanium, or nitinol. These materials are selected for durability, corrosion resistance, and compatibility with human tissue during internal therapeutic procedures. - In which medical procedures are endoscopic clips most commonly applied?
Endoscopic clips are widely used in procedures such as gastrointestinal bleeding management, polypectomy closure, perforation repair, and post-surgical marking. Their use supports faster healing while reducing the need for open surgical intervention. - Are endoscopic clips permanent or removable?
Most endoscopic clips are designed to detach naturally and pass through the digestive tract within several days to weeks. Certain advanced clip systems, however, can be repositioned or retrieved during the procedure if required. - What are the advantages of using endoscopic clips over surgical sutures?
The use of endoscopic clips enables minimally invasive treatment, reduced procedure time, lower complication rates, and faster patient recovery. These advantages have increased their adoption as a preferred alternative to conventional surgical suturing. - What factors are driving the growth of the endoscopic clips market?
Market growth is driven by rising gastrointestinal disease prevalence, increasing demand for minimally invasive procedures, and technological advancements in endoscopy devices. Expanding healthcare infrastructure and higher procedure volumes further support sustained market expansion. - How is technological innovation influencing the endoscopic clips market?
Technological advancements such as rotatable clips, improved deployment mechanisms, and enhanced gripping strength have improved procedural accuracy. These innovations have increased clinician preference, supporting wider adoption across hospitals and ambulatory surgical centers. - Which end-user segments dominate the endoscopic clips market?
Hospitals represent the largest end-user segment due to high procedure volumes and advanced endoscopy facilities. Ambulatory surgical centers are also gaining share, supported by cost efficiency and the growing shift toward outpatient gastrointestinal procedures. - How does regional demand vary in the endoscopic clips market?
North America and Europe lead the market due to advanced healthcare systems and early technology adoption. Asia-Pacific is expected to experience faster growth, driven by expanding medical infrastructure and rising awareness of minimally invasive treatments.
Conclusion
In conclusion, the global endoscopic clips market is positioned for sustained and stable growth, driven by the rising adoption of minimally invasive gastrointestinal procedures and increasing prevalence of digestive disorders. Continuous technological advancements in clip design, improved clinical outcomes, and growing physician awareness are strengthening market acceptance across healthcare settings.
Favorable reimbursement policies in developed regions and expanding endoscopy infrastructure in emerging economies further support market expansion. With hospitals remaining the primary end users and hemostasis as the dominant application, the market outlook remains cautiously optimistic, underpinned by innovation, procedural efficiency, and improving patient safety standards.
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