Table of Contents
Overview
New York, NY – Aug 12, 2025 : The global Gene synthesis service market is projected to grow from US$ 2.1 billion in 2024 to US$ 16 billion by 2034. This reflects a strong CAGR of 22.5% from 2025 to 2034. The market’s growth is mainly driven by rapid developments in synthetic biology and biotechnology. Rising demand for custom DNA synthesis across various sectors is fueling this momentum. Increasing adoption of gene editing tools and next-generation sequencing is also supporting the market expansion, particularly in healthcare, diagnostics, and pharmaceutical research.
Advancements in synthetic biology are significantly improving the accuracy and speed of gene synthesis. These innovations are making it easier to create custom DNA sequences. As a result, gene synthesis is being used in a wide range of applications. These include gene therapy, vaccine development, and clinical diagnostics. The move towards precision medicine is a major growth factor. Personalized medicine requires tailored genetic solutions, which increases the need for fast and accurate gene synthesis services across research and clinical domains.
Rising investments in genomics and biotechnology are accelerating innovation. Governments and private entities are funding research heavily in synthetic biology. This trend supports the development of faster and more reliable gene synthesis workflows. However, some hurdles remain. These include ethical issues around synthetic DNA and concerns over misuse. Technical challenges, such as synthesizing long DNA sequences and integrating them into functioning systems, also persist. Despite this, ongoing advancements in automation and sequencing technology are steadily overcoming these barriers.
North America leads the global gene synthesis service market. The region benefits from advanced biotechnology infrastructure and a strong funding landscape. A high concentration of leading biotech firms also contributes to its dominance. Many companies in North America are launching new solutions to reduce synthesis turnaround times. This supports applications in drug development, diagnostics, and personalized therapies. Additionally, academic institutions and government labs continue to play a key role in driving gene synthesis research and commercialization.
In June 2024, GenScript Biotech introduced the FLASH Gene service. This offering delivers plasmid DNA within four business days. The flat-rate pricing starts at $89 and includes synthesis, cloning, and plasmid preparation. The service guarantees both sequence accuracy and plasmid yield. It benefits researchers in vaccine development, gene therapy, and antibody engineering. Earlier, in November 2023, Twist Bioscience launched Express Genes. This service offers gene synthesis in five to seven business days. It includes midiprep and maxiprep DNA formats. All constructs undergo next-generation sequencing for quality assurance.
Key Takeaways
- In 2024, the global gene synthesis service market was valued at USD 2.1 billion, expected to reach USD 16.0 billion by 2034.
- The market is set to grow at a strong CAGR of 22.5% from 2025 to 2034, reflecting rising demand in biotechnology applications.
- Solid-phase synthesis dominated in 2024, accounting for 46.7% of total global revenue due to its high efficiency and wide use in labs.
- Antibody DNA synthesis led the service type segment with a 60.4% revenue share, driven by increased demand in immunotherapy and diagnostics.
- Gene and cell therapy development held the top spot among applications, contributing 36.2% of revenue, fueled by breakthroughs in personalized medicine.
- Biotechnology and pharmaceutical firms were the largest end-users in 2024, capturing 52.4% market share due to ongoing drug and vaccine development.
- North America remained the dominant regional market, generating over 42.1% of global revenue thanks to strong research infrastructure and funding support.
Regional Analysis
The North America gene synthesis service market is growing rapidly. Advancements in synthetic biology and demand for personalized medicine are key drivers. Investments in biotechnology research and development are rising. New technologies, such as artificial intelligence and automation, are improving efficiency and accuracy. These tools help reduce errors and speed up research. Twist Bioscience’s Twist Express Genes offers rapid synthesis at all gene prep scales. This service benefits researchers in multiple sectors, supporting faster innovation and better research outcomes.
Chronic diseases like cardiovascular disorders and cancer are increasing. This trend is creating higher demand for innovative treatments. Personalized therapeutics need genes tailored to individual profiles. As a result, the demand for gene synthesis services is rising. Companies are focusing on precision medicine to deliver targeted solutions. These developments are making the market more dynamic. With technological progress and growing healthcare needs, North America is seeing strong growth in gene synthesis services. The future outlook for this market is highly promising.
Segmentation Analysis
In 2024, the solid-phase synthesis method held the largest share of 46.7% in the global gene synthesis service market. This method is known for its efficiency, scalability, and accuracy in producing complex DNA sequences. It involves attaching DNA to a solid support, allowing stepwise addition of nucleotides with precision. This ensures high-quality results and consistent sequence accuracy. The ability to perform parallel synthesis reduces production time. Solid-phase synthesis is widely used in gene therapy, vaccine production, and synthetic biology due to its adaptability and reliability.
By services, antibody DNA synthesis dominated the global gene synthesis service market with a 60.4% share in 2024. It plays a critical role in developing therapeutic antibodies, vaccines, and diagnostic tools. This method enables the design of antibodies with improved binding affinity and targeted specificity. Demand is growing in cancer immunotherapy and autoimmune disease treatments. Innovations from companies like Twist Bioscience and Codex DNA have boosted efficiency. The integration of automation and digital technologies is streamlining workflows, ensuring faster antibody discovery and large-scale production capabilities.
Gene and cell therapy led the market by application, capturing a 36.2% share in 2024. These therapies are transforming treatment for genetic disorders and advancing personalized medicine. Gene synthesis services enable the creation of synthetic genes for CRISPR-based treatments, CAR-T cells, and engineered therapies. The rise in genetic diseases and cancers fuels demand. Integration with CRISPR-Cas systems and synthetic biology has improved precision and efficiency. These services are also essential in vaccine development and genetic engineering, ensuring continued dominance in therapeutic innovation and clinical applications worldwide.
By end-use, biotechnology and pharmaceutical companies accounted for 52.4% of the global gene synthesis service market in 2024. These companies rely on gene synthesis for gene therapy, vaccine development, and monoclonal antibody production. Leading firms such as GenScript, Twist Bioscience, Novartis, and Bristol-Myers Squibb collaborate with service providers to accelerate R&D. Gene synthesis integration into the drug discovery process enables rapid, cost-effective creation of targeted therapies. The growing emphasis on personalized medicine is driving demand for custom DNA sequences, cementing this segment’s leading role in market growth and innovation.
Key Players Analysis
The gene synthesis service market is growing rapidly, driven by leading players such as GenScript, Thermo Fisher Scientific, Integrated DNA Technologies, Eurofins Genomics, and Twist Bioscience. These companies are focusing on innovation, automation, and artificial intelligence to enhance accuracy and efficiency in synthesis processes. For example, GenScript offers the Twist Express Genes platform for rapid gene synthesis at multiple scales. Twist Bioscience uses a silicon-based platform for high-throughput DNA synthesis. These advancements help reduce costs, speed up delivery, and meet the rising demand in biotechnology and pharmaceutical research.
Strategic collaborations and partnerships are shaping the competitive landscape as companies aim to expand market reach and technical capabilities. Regulatory changes, such as U.S. synthetic DNA screening protocols, influence operational practices. The market benefits from strong demand for customized genetic solutions and continuous innovation in synthesis technology. With reduced turnaround times, improved accuracy, and scalable production, the industry is poised for further growth. The environment remains highly competitive, driven by technological progress and evolving research needs across global biotech and pharma sectors.
Emerging Trends
1. More Demand for Custom DNA Sequences
There is a growing need for tailor-made DNA sequences. Researchers and companies want DNA that fits their specific project requirements. This is driving service providers to create more customizable synthesis options. These services allow scientists to design and order sequences with high precision. Custom DNA supports faster innovation in medicine, agriculture, and industry. It helps in developing new drugs, improving crops, and creating eco-friendly solutions. The shift toward personalized DNA synthesis means the market is expanding. More organizations now prefer on-demand, made-to-order sequences instead of generic solutions. This trend is becoming a major driver of growth.
2. Rise of Automation and AI in Synthesis
Gene synthesis is becoming faster and more accurate thanks to automation and AI. Advanced machines can now produce sequences with fewer errors. AI tools help design genes more efficiently and predict the best sequence combinations. This technology reduces costs and speeds up delivery times. Researchers no longer have to wait weeks for results. Automated systems also minimize the need for manual labor. This reduces human errors and increases reliability. The integration of AI means complex projects are easier to handle. Overall, automation and AI are transforming the gene synthesis industry into a more efficient, high-speed sector.
3. Growing Interest in Synthetic Biology
Synthetic biology is emerging as a major innovation field. It involves creating or redesigning organisms for specific uses. Gene synthesis is at the heart of this process. It provides the building blocks needed to engineer new organisms. These can be used in healthcare, agriculture, and environmental protection. In healthcare, synthetic biology can lead to new treatments and vaccines. In agriculture, it can help grow more resilient crops. For the environment, it can create organisms that clean up pollution. This expanding interest is making gene synthesis an essential tool for future biotechnology breakthroughs.
4. Cost Reduction Through New Technologies
New synthesis methods are cutting costs significantly. Advanced techniques reduce the amount of expensive materials needed. They also lower the time required for production. This makes gene synthesis more affordable for small research teams and startups. Lower costs mean more organizations can access these services. This creates more opportunities for innovation. Affordable synthesis helps speed up discoveries in medicine, agriculture, and energy. As technology improves, prices are expected to drop even further. Cost reduction is one of the strongest factors driving market growth. It is helping make gene synthesis accessible to a wider range of users.
5. Collaboration Between Academia and Industry
Partnerships between universities, biotech startups, and pharmaceutical companies are increasing. These collaborations combine academic research expertise with industry resources. Together, they can develop new gene-based solutions faster. Academic teams bring fresh ideas and deep scientific knowledge. Industry partners provide advanced equipment, funding, and production capabilities. This teamwork accelerates innovation in healthcare, agriculture, and industrial applications. Many breakthrough discoveries are now coming from such partnerships. These collaborations also help train future scientists and strengthen the overall gene synthesis ecosystem. The blending of academic and commercial strengths is creating a powerful innovation network.
6. Expanding Applications Beyond Medicine
Gene synthesis is now used in more industries than ever before. Beyond medicine, it is helping produce biofuels, improve food production, and protect the environment. In energy, engineered genes create microorganisms that produce renewable fuels. In agriculture, gene synthesis develops crops that grow faster and resist pests. In environmental work, custom genes help design organisms that break down waste or toxins. These non-medical uses are opening new market opportunities. They also reduce dependence on traditional, less sustainable methods. As applications expand, gene synthesis is set to become an essential tool across multiple global industries.
Use Cases
1. Drug Discovery and Development
Pharmaceutical companies use gene synthesis to design and produce custom DNA sequences. These sequences help them study how diseases work at a genetic level. With this knowledge, they can identify new drug targets and develop treatments faster. Instead of relying on traditional trial-and-error methods, synthetic genes make the process more precise. Researchers can create models of diseases in the lab to test potential drugs. This speeds up early-stage research and increases the chances of finding effective therapies. The result is shorter development timelines, reduced costs, and a better understanding of how to treat complex health conditions.
2. Vaccine Development
Gene synthesis is transforming how vaccines are developed. Scientists can now create the exact genetic material needed for modern vaccines, including mRNA-based and DNA-based types. This technology was key in the rapid development of COVID-19 vaccines. With synthetic genes, researchers can quickly design vaccine candidates to target new or emerging diseases. It also allows them to update existing vaccines when viruses mutate. This flexibility shortens production time and helps respond to global health threats more effectively. The ability to create vaccines in weeks instead of years is a major breakthrough in protecting public health worldwide.
3. Agricultural Improvements
Gene synthesis is playing a big role in making farming more efficient and sustainable. Scientists can design plant genes that make crops more resistant to pests, diseases, and extreme weather. For example, they can create seeds that grow in drought-prone areas or have higher nutritional content. This helps farmers reduce the need for chemical pesticides and fertilizers. It also increases food production in regions facing climate challenges. By using synthetic genes, agriculture can become more resilient and eco-friendly. These advancements aim to meet the growing demand for food while reducing the impact on the environment.
4. Industrial Biotechnology
In industrial biotechnology, gene synthesis allows companies to design microorganisms with special abilities. These engineered microbes can produce biofuels, biodegradable plastics, and other eco-friendly materials. This reduces reliance on fossil fuels and lowers environmental pollution. For example, certain bacteria can be programmed to produce enzymes that break down plant waste into renewable energy. Synthetic genes make these processes faster and more cost-effective. They also help create materials with better performance, such as stronger bioplastics. This technology is helping industries shift toward greener, more sustainable production methods, supporting the global move toward a circular economy.
5. Gene Therapy Research
Gene synthesis is a key tool in developing gene therapy treatments. Researchers can design healthy genes to replace faulty ones that cause genetic disorders. These synthetic genes are tested in the lab to ensure they work safely and effectively. The approach holds promise for treating conditions such as cystic fibrosis, muscular dystrophy, and certain types of blindness. By creating accurate copies of functional genes, scientists can restore normal biological functions in patients. Gene synthesis speeds up this process, making it easier to develop new therapies. This brings hope for curing diseases once thought to be untreatable.
6. Environmental Applications
Synthetic genes are being used to create microorganisms that can help clean the environment. These engineered microbes can break down toxic chemicals, plastics, and other pollutants. For example, scientists have designed bacteria that can digest oil spills in the ocean. This process, known as bioremediation, offers a natural and sustainable way to restore damaged ecosystems. Gene synthesis allows for the rapid design and testing of these microbes. It also makes it possible to adapt them for different environments, such as soil, water, or industrial waste sites. This technology plays a vital role in environmental protection and restoration.
Conclusion
The gene synthesis service market is set for strong growth, driven by advances in synthetic biology, automation, and artificial intelligence. Increasing demand for custom DNA sequences across healthcare, agriculture, and industrial biotechnology is fueling innovation. The shift toward personalized medicine is creating more opportunities for tailored genetic solutions, while new technologies are reducing costs and improving turnaround times. Strong research infrastructure, rising investments, and expanding applications beyond medicine are further boosting market potential. With leading companies focusing on quality, speed, and scalability, the industry is moving toward faster, more accessible, and more precise genetic services. This positions gene synthesis as a vital driver of future scientific and medical breakthroughs.
View More
Gene Synthesis Market || Gene Therapy Market || Cancer Gene Therapy Market || Gene Editing Market || Gene Therapy in CNS Disorder Market || Gene Expression Market || Cell And Gene Therapy Manufacturing Market || Cell and Gene Therapy CDMO Market || Gene Panel Market || Cell and Gene Therapy Market
Discuss your needs with our analyst
Please share your requirements with more details so our analyst can check if they can solve your problem(s)
