Knee Osteoarthritis Treatment Market to Expand at 7.7% CAGR by 2034

Overview

New York, NY – Aug 07, 2025 : Global Knee Osteoarthritis Treatment Market is set to grow from US$ 6.21 Billion in 2024 to around US$ 13.04 Billion by 2034. This marks a CAGR of 7.7% during the forecast period. The rising elderly population and increased life expectancy are key factors boosting market demand. Knee osteoarthritis (KOA), often linked to aging, is a degenerative joint condition that affects millions worldwide. As the condition worsens over time, patients often require long-term treatment and care, driving the market’s steady growth.

KOA is commonly known as wear-and-tear arthritis of the knee. It involves gradual cartilage breakdown, leading to joint pain and reduced mobility. There are two types: primary and secondary osteoarthritis. Primary KOA develops without any clear cause. Secondary KOA results from factors like trauma, obesity, or rheumatoid arthritis. The disease is progressive and, in severe cases, leads to disability. This increases the need for ongoing treatments to manage pain and prevent further joint damage.

The treatment market is divided into non-surgical and surgical segments. Non-surgical options include pain relief medications such as NSAIDs, corticosteroid injections, and hyaluronic acid. Physical therapy and assistive devices also play key roles in symptom management. On the surgical side, knee replacement surgeries are widely performed. These include Total Knee Replacement (TKR) and Unicompartmental Knee Arthroplasty. Growing demand for these procedures is driven by patients seeking long-term mobility improvement and pain relief.

New treatment approaches are changing the market landscape. Regenerative therapies, such as stem cell therapy and platelet-rich plasma (PRP), are gaining traction. These aim to repair damaged cartilage and delay surgery. Digital health tools, including wearable knee braces and mobile apps, are helping track symptoms and progress. These advancements provide patients with more options and improve their quality of life. As a result, healthcare providers are exploring a more personalized treatment approach for KOA patients.

Despite innovation, the market faces challenges. High treatment costs, especially for surgeries and biologics, limit access in some regions. Long-term management can also be financially burdensome for patients. However, ongoing research and development in minimally invasive procedures and biologic drugs show promise. The global focus on improving elderly care and chronic disease management further supports growth. Overall, the Knee Osteoarthritis Treatment Market holds strong potential, backed by aging demographics and continued technological progress.

Key Takeaways

• In 2024, the global knee osteoarthritis treatment market generated revenue of US$ 21 billion, growing steadily at a CAGR of 7.7%.
• Projections suggest the market will decline to approximately US$ 13.04 billion by 2034, despite current growth momentum in treatment innovations.
• Among treatment options, non-surgical methods led the way in 2023, capturing a significant 62.5% share of the total treatment market.
• Oral administration emerged as the most preferred route, accounting for 41.8% of the market due to ease of use and patient compliance.
• Hospitals proved to be the top end user segment, holding 46.3% of total market revenue, thanks to advanced care and infrastructure.
• North America dominated the knee osteoarthritis treatment space in 2023, capturing a commanding 62.5% market share across the region.

Regional Analysis

The Knee Osteoarthritis (KOA) Treatment Market in North America is growing rapidly. This growth is mainly due to an aging population and improved medical technologies. In the U.S. and Canada, knee osteoarthritis is becoming more common as more people age. Non-surgical treatments like physical therapy, NSAIDs, corticosteroids, and hyaluronic acid injections are widely used. New regenerative therapies such as Platelet-Rich Plasma (PRP) and stem cell treatments are also gaining popularity. These methods aim to repair damaged joints and delay the need for surgery.

Hospitals are the main providers of KOA treatment across the region. They offer both surgical and non-surgical options under one roof. For severe cases, knee replacement surgery remains a widely used method. North America benefits from advanced healthcare systems and strong investments in R&D. This has made the region a leader in adopting innovative treatments. The market is expected to grow further as more people seek effective, long-term solutions for joint pain and mobility issues.

Segmentation Analysis

Treatment Type Analysis

Non-surgical treatments lead the Knee Osteoarthritis Treatment Market, holding a 62.5% share. This is due to their affordability, accessibility, and non-invasive nature. NSAIDs are the most prescribed drugs, providing pain relief and reducing inflammation. Corticosteroids and analgesics are also widely used, especially for moderate to severe cases. Hyaluronic Acid Injections are common for improving mobility by lubricating the joint. Newer options like PRP therapy and stem cell injections are gaining traction for their regenerative benefits. These options appeal to patients seeking early-stage, long-term management without surgery.

Route of Administration Analysis

Oral administration dominates the market with a 41.8% share, mainly for its convenience and cost-efficiency. NSAIDs and analgesics taken orally are typically the first step in treating knee osteoarthritis symptoms. Patients prefer oral treatments because they don’t require injections or medical supervision. These medications are often available over-the-counter and used for continuous symptom relief. Oral forms of corticosteroids and hyaluronic acid are also growing in use. This route’s popularity stems from easy access, patient comfort, and proven effectiveness in controlling inflammation and pain.

End User Analysis

Hospitals account for 46.3% of the Knee Osteoarthritis Treatment Market. They offer both surgical and non-surgical options under one roof. Their advanced infrastructure and equipment support procedures like knee replacement and arthroscopy. Hospitals also provide physical therapy, PRP injections, and pain management services. Specialized orthopedic departments create customized treatment plans for complex OA cases. Access to multidisciplinary teams, including surgeons and physiotherapists, strengthens their position. Hospitals are preferred by patients with advanced-stage knee OA who require a range of high-quality care services in one setting.

Key Players Analysis

Key players in the Knee Osteoarthritis (KOA) Treatment Market include major pharmaceutical and medical device companies such as Pfizer Inc., Sanofi S.A., and Novartis AG. Pfizer leads in developing medications for inflammatory conditions like KOA. The company provides pain relief options, especially NSAIDs, and invests in biologics for better treatment outcomes. Sanofi also offers therapies targeting joint inflammation and focuses on innovative treatment strategies. Both companies aim to improve long-term care for KOA patients through continued research and development in this area.

Novartis AG is another key player in the KOA treatment space. The company is exploring biologic and regenerative therapies to slow disease progression. Its research focuses on targeting inflammation and joint degeneration through novel drugs. Novartis aims to go beyond standard pain relief by offering advanced treatment options. These companies, along with others like AbbVie, Amgen, and Zimmer Biomet, play a crucial role in shaping the future of KOA treatment through innovation, product development, and strategic collaboration in the healthcare market.

Emerging Trends

• Rising Demand for Non-Surgical Treatments: More people are choosing non-surgical options to manage knee osteoarthritis. Treatments like physical therapy, non-steroidal anti-inflammatory drugs (NSAIDs), and hyaluronic acid injections are becoming popular. These options are less risky, more affordable, and offer faster recovery compared to surgery. Many patients prefer to avoid invasive procedures and downtime. Non-surgical methods can also be used earlier in the disease to delay or prevent surgery. As awareness grows, healthcare providers are recommending these treatments more often. This shift is driving market growth, especially among older adults and those with mild to moderate symptoms.
• Growth in Regenerative Medicine: Regenerative therapies like stem cell and platelet-rich plasma (PRP) treatments are gaining attention. These methods aim to repair or rebuild damaged knee cartilage. Unlike pain relievers that offer short-term relief, regenerative medicine focuses on long-term healing. Patients are drawn to these options because they are natural and may slow disease progression. Clinics offering these treatments are increasing, especially in urban areas. Although still developing, early results are promising. This trend shows a shift toward innovative, non-invasive options that could reduce the need for surgery in the future.
• Increased Use of Personalized Medicine: Doctors are now using more personalized treatment plans for knee osteoarthritis. Instead of one-size-fits-all approaches, care is now tailored to each person’s age, weight, lifestyle, and the severity of their condition. This helps improve treatment outcomes and reduce side effects. For example, a younger patient may benefit from regenerative therapies, while an older patient might respond better to physical therapy and medications. Personalized care supports better decision-making and long-term results. This trend is expected to grow as technology and medical knowledge continue to improve.
• Technological Advancements in Surgical Procedures: When surgery is necessary, new technologies are improving outcomes. Robotic-assisted knee replacements and minimally invasive procedures are now more common. These methods help surgeons operate with greater precision. As a result, patients experience less pain, shorter hospital stays, and faster recovery times. Advanced imaging and surgical tools also lower the risk of complications. Many hospitals are adopting these innovations to meet growing demand. While surgery remains a last resort for many, these improvements are making it safer and more effective for those who need it.
• Digital Health Integration: Digital tools are playing a bigger role in knee osteoarthritis treatment. Wearables and smartphone apps help patients track their pain, movement, and overall progress. This data can be shared with doctors in real-time. It supports remote monitoring, which is helpful for older adults or those in rural areas. Digital health also improves patient engagement, as people can follow their treatment plans more closely. With better tracking, doctors can adjust therapies faster if needed. This tech-driven approach is improving long-term care and making treatments more accessible.
• Focus on Early Diagnosis and Prevention: There is a stronger push for early diagnosis of knee osteoarthritis. Doctors are using imaging tests and biomarkers to spot the disease in its early stages. Catching it early allows for faster treatment, which can slow down joint damage. This may delay or even prevent the need for surgery. Health campaigns are also raising awareness about risk factors like obesity and injury. More people are now getting screened before symptoms become severe. This trend is helping patients live more active lives and reduce future healthcare costs.

Use Cases

• Elderly Patient Care in Clinics and Hospitals: Older adults often visit orthopedic clinics or hospitals for knee pain caused by osteoarthritis. Doctors usually begin treatment with pain-relief medications or recommend physical therapy. These early treatments are less invasive and help improve movement. If the condition gets worse, doctors may suggest corticosteroid injections to reduce swelling. In severe cases, a total or partial knee replacement surgery is advised. Clinics focus on easing pain, improving mobility, and slowing down joint damage. Elderly patients also receive guidance on lifestyle changes and assistive devices like walking aids. Regular follow-ups help track progress and adjust treatment as needed.
• Sports Injury Management: Younger or middle-aged adults often face early osteoarthritis after joint injuries from sports. These patients visit orthopedic or sports injury clinics. Common treatments include platelet-rich plasma (PRP) therapy, which helps heal joint tissues. Physical therapy is also used to strengthen muscles and reduce stress on the knee. Some wear joint support braces to avoid further damage. These treatments aim to control pain and delay the need for surgery. Doctors may also suggest low-impact exercises and anti-inflammatory medications. Quick diagnosis and personalized care plans help improve recovery and prevent long-term joint issues.
• At-Home Rehabilitation Programs: Many patients now choose home-based programs to manage mild osteoarthritis or recover from knee surgery. These plans are cost-effective and easy to follow. They include daily physical exercises to improve joint strength and flexibility. Patients often use knee braces and assistive devices to support their knees. Virtual check-ins with healthcare providers offer ongoing guidance and motivation. Some programs also offer mobile apps to track progress. At-home care reduces the need for frequent hospital visits. It also empowers patients to take control of their recovery journey in a safe, familiar environment.
• Use in Physical Therapy Centers: Physical therapy centers play a key role in treating knee osteoarthritis. Therapists design personalized exercise plans to strengthen muscles around the knee. These exercises help reduce pain and improve movement. Therapists also use methods like heat and cold therapy to ease swelling. Electrical stimulation is another tool used to improve joint function. Regular sessions focus on building strength, restoring flexibility, and reducing stiffness. Therapy centers also educate patients on proper body mechanics. This helps prevent further injury. These non-invasive methods are especially useful for people who want to avoid surgery.
• Orthopedic Device and Implant Use in Hospitals: In advanced cases of knee osteoarthritis, hospitals perform surgeries to replace damaged joints. Total or partial knee replacement is the most common approach. Surgeons now use high-quality implants for better outcomes. Some hospitals also use 3D-printed components for a more customized fit. These implants improve joint mobility and reduce long-term pain. After surgery, patients follow a structured rehab plan to regain strength. Hospitals ensure safety and fast recovery through advanced tools and skilled orthopedic teams. Long-term follow-up helps monitor implant performance and overall patient health.
• Pain Management Clinics: Pain management clinics offer solutions for patients who don’t get relief from standard treatments. These clinics focus on reducing chronic knee pain without surgery. Doctors use a mix of oral medications, corticosteroid or hyaluronic acid injections, and sometimes nerve blocks. These treatments target pain at its source. Clinics often work with physical therapists to improve outcomes. Patients also get advice on lifestyle changes, diet, and exercise routines. The goal is to control pain, improve function, and delay invasive procedures. These centers provide a well-rounded care plan tailored to each patient’s needs.

Conclusion

In conclusion, the Knee Osteoarthritis Treatment Market is growing steadily due to rising awareness, better treatment options, and an aging global population. People are increasingly choosing non-surgical methods, such as physical therapy and pain medications, for early management. At the same time, advanced treatments like stem cell therapy and robotic surgeries are gaining attention for severe cases.

The market also benefits from digital health tools that improve patient care at home. While high treatment costs remain a concern, innovation and early diagnosis are helping more people manage their condition effectively. Overall, the market shows strong potential for future growth as healthcare providers focus on personalized and long-term care solutions.

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