A nasal Covid vaccine could soon become a reality. Researchers have found that an intranasal vaccine. The vaccine provides a guard against Covid-19 infection. An experiment in the UK has shown potential signs of full protection from the vaccine against the disease. The experiment was done on mice. Researchers used a vaccine containing a parainfluenza virus 5 or PIV5. PIV5 is harmless. They delivered the SARS-CoV-2 spike protein into the cells of mice. They found that mice produced an impressive immune response. The antibodies provide enough protection against SARS-CoV-2 which causes Covid-19 infection. The inhaled vaccine also blacked the transmission of the virus from infected mice to those uninfected.
Besides giving protection against Covid-19, researchers said that the vaccine prevents other infections and diseases. They said that vaccines that are currently available are very effective against Covid-19 infection. But they are intramuscular injections. It requires trained medical personnel to administer the drug. Also, the current vaccines are two-shot drugs. While countries like the US, UK, and others are providing vaccines to their people, the majority of the world’s population is still unvaccinated. There is a need for more vaccines. Vaccines that are easy to use can bolster the fight against infection. The nasal vaccine will help in stopping disease and transmission early.
Researchers called for a clinical trial to understand the vaccine’s efficacy. If the vaccine is effective and safe in humans, it will be a vital weapon in controlling the Covid-19 pandemic. Researchers said that PIV5 is related to common cold viruses. It easily infects mammals including humans and doesn’t cause any significant disease. The vaccine can be inhaled, thus cutting the need for a medical person to administer the drug and also the need for a syringe. PIV5 directly targets mucosal cells. It clears the nasal passages and airways. Past studies said that mucosal cells are the main entry point for the virus. It is also the site in the human body for its early replication. Viruses replicated in these cells invade deeper into the lungs and other organs. This leads to difficulty in breathing and severe disease.